Belgium
A dedicated Senior associate scientist with a strong passion for advancing analytical method development using UPLC and HPLC. I have extensive experience in a wide range of analytical techniques, experimental design, method validation, performance evaluation, and transferring methods from HPLC to UPLC. Problem-solving and addressing complex investigative challenges are among my greatest strengths. With over five years of experience in the pharmaceutical industry, I am committed to deepening my expertise by applying practical statistical methods to support analytical science. My transition from engineering to laboratory-based work underscores my strong commitment to excelling in this field.
In the AnaBiotec lab, my responsibilities include conducting analytical analysis of biomolecules using techniques such as Reverse Phase Chromatography (RPC), Ion Exchange Chromatography (IEX), Size Exclusion Chromatography (SEC), and Peptide Mapping (PepMap). The main responsibilities involved, • Developing methods for detection of surfactants and excipients in dissolution samples using ELSD detector. • Designing effective experiments • Transferring method from HPLC to UPLC • Validation of analytical methods • Transferring methods between different laboratory setups. • Verification of validation results using JMP • Proficiency in performing calculations using EMPOWER. • Developing validated Excel spreadsheets for method-specific calculations. • Conducting Buffer Exchange (BEX), Biopotency (BPO) assays. and Lincker Cleavage (LIC) techniques for specific analyses.
- Separation of proteins (Adalimumab, Cinnal-f, CinnoVex, SpikoGen, Cinnatropin, Cinnapoietin, etc) by liquid chromatography method - Preparation of sample before injection - Quantitative and qualitative tests like RP-Purity, RP-Assay, Glycan-Mapping, Peptide-Mapping, SE, and IEC for proteins - Analysis by different detectors like DAD, FLD, and ELSD - Analysis with a different types of columns in various methods - Gradient and isocratic elution
Responsible for the design, development, and formulation of new drugs to improve the quality of products, customer needs, and all the steps of Advancement of a pharmaceutical formulation, from the pre-formulation stage to the experimental and industrial batch production and validation, manufacturing, and testing methods which lead to the compilation of the CTD drug file. Responsible for setting up, calibrating, repairing, and maintaining devices: - HPLC, Spectrophotometer, Melting Point, Atomic Absorption, and Polarimeter - Tablet Hardness tester, Tablet dissolution tester, Tablet Disintegration tester, Osmometer, Tablet press, and Stability test chamber - Oven, Incubator, Bain-marie, and Scale
Head of pharmaceutics 2&3 lab Responsible for setting up, calibrating, repairing, and maintaining devices