Greater Kuala Lumpur
- Generate and characterize humanized transgenic and knock-in mouse models to study breast cancer/Fanconi anemia related BRCA2 mutation - Assess the pathogenicity of human breast and/or ovarian cancer related BRCA2 variants of unknown clinical significance (VUS), in mouse embryonic stem cells, using the BAC recombineering technology - Trained interns under the Werner Kirsten internship programme
Analysed the spectrum and prevalence of BRCA1 and BRCA2 related breasts cancer mutations in Malaysia’s multiethnic population - extensive experience in working with clinicians, clinical staffs, researchers/academicians and the public in order to maintain/establish collaborations and to create awareness about the study - have experience in obtaining ethics approval for the study at collaborating centers, and was successful in obtaining research grants - generated documents to collect patient information and epidemiological data and trained certified nurses to interview and recruit breast and ovarian cancer patients, and coordinate blood and tissue collection at collaborating centers - established and maintained database of breast cancer patients recruited into the study - established the high-throughput genotyping platform: Sequenom, which allows genotyping of 25-37 mutations in 384 patients simultaneously - lead in assay and experimental design, and trained research assistants on the running, data analysis, management, and up-keep of Sequenome Trained student(s) from collaborating lab, and total of 12 industrial trainees and final year project students between Mar 2005 – Mar 2009