Frankfurt Rhine-Main Metropolitan Area
Synthesis of new Ruthenium complexes and applications in cellular imaging
„DNA repair mechanisms: Synthesis and evaluation of mechanistic based enzyme inhibitors for DNA polymerase β“ Mentor: Prof. Dr. Marc M. Greenberg -Synthesized a series of nucleotide based irreversible inhibitors containing the dioxobutane fragment -Produced several libraries of small molecules (each containing about 230 compounds) using a fragment based approach and examined their selective irreversible inactivation of DNA polymerase β -Discovered a series of mechanism based inhibitors and quantified the lyase activity inhibition using radiolabeled DNA substrates containing 5’-deoxyribophosphate lesion -Examined the mechanism of DNA polymerase β inactivation by the inhibitors using a variety of chemical and biochemical methods
-Synthesized and characterized a wide variety of insect pheromones -Developed and executed synthetic routes for complex molecules (up to 13 steps) on scales that ranged from milligrams to several hundred grams -Modified and optimized the synthetic procedures and developed analytical methods for establishing product purity -Conducted synthesis for clients (European and Russian companies) within tight timeline