Lucknow, Uttar Pradesh, India
PhD in reproductive biology with research experience in genomics, miRNA biology, and genetics. My doctoral work focused on understanding the molecular and genetic mechanisms underlying impaired spermatogenesis, with an emphasis on integrating high-throughput sequencing, variant interpretation, and functional insights. During my PhD, I have worked extensively on genetic variant analysis, genotype–phenotype correlations, and molecular pathways involved in sperm development and function. I am particularly interested in how RNA biology, epigenetic regulation, and structural gene defects contribute to male infertility, and how these findings can be translated into improved diagnostics and reproductive health outcomes. I am currently exploring postdoctoral and research opportunities in: -Male reproductive biology -Functional and human genomics -RNA biology and gene regulation -Translational genetics and molecular diagnostics 📌 Always open to scientific discussions, collaborations, and research-focused networking.
Thesis title: Investigation of miRNA dynamics in testicular germ cells and genetic causes of male infertility.
Investigated the genetic basis of male infertility, focusing on sperm morphological abnormalities and genotype–phenotype correlations using whole-exome sequencing (WES). Performed piRNA expression and differential alternative splicing analysis under heat stress conditions in round spermatids and pachytene spermatocytes, identifying stress-responsive molecular signatures. Identified and evaluated miRNA candidates as potential biomarkers of male infertility through integrated transcriptomic and functional analysis. Studied the impact of heat stress on germ cells, uncovering changes in gene expression, alternative splicing, and small RNA dynamics associated with disrupted spermatogenesis. Authored and peer-reviewed publications and book chapters on small RNA biology, genetic mutations, and Y-chromosome microdeletions in male infertility. Applied a combination of molecular biology techniques and bioinformatics tools to integrate experimental and computational findings in support of mechanistic insights and potential diagnostic applications. Involved in the establishment of CRISPR-based gene knockout experiments to functionally validate candidate genes identified.