Jabriya, Hawalli, Kuwait
My research focused on two main interconnected areas: computational vaccine design and structural biochemistry of thermophilic enzymes. On the vaccine side, my team uses reverse vaccinology and immunoinformatics to design multi-epitope vaccine candidates — work we’ve applied to both SARS-CoV-2 and bladder cancer. Critically, we don’t stop at the computer: our SARS-CoV-2 vaccine candidate was expressed in E. coli, purified, and validated in live animal immunization trials, achieving IgG antibody titers detectable up to a 1:256,000 dilution. On the structural biology side, I investigate how thermophilic serine proteases behave under extreme temperature and pH conditions — combining molecular dynamics simulations with fluorescence spectroscopy and circular dichroism to understand protein stability and folding, including the Molten Globule phenomenon. My work has been published in journals including the Journal of Molecular Structure (IF: 3.841), Journal of Biomolecular Structure and Dynamics (IF: 3.310), and Immunogenetics (IF: 2.649), in collaboration with researchers internationally. I welcome connections in vaccine development, structural biology, enzyme biotechnology, and computational immunology. I also have a strong research interest in pharmacogenomics — specifically, the genetically determined variability in individual drug response. By studying how a person’s genetic inheritance influences the body’s reaction to drugs, and by genotyping key DNA polymorphisms in metabolic and signal transduction pathways, my goal is to help predict therapeutic failures and severe adverse drug reactions before they occur — moving medicine closer to a truly personalized approach.
Member of the Postgraduate Committee at Faculty of Allied Heath Sciences, KUNIV Member of the Technical committee at the Research Unit for Genomics, Proteomics and Cellomics Sciences/Research Core Facility Member of the Budget Committee at Faculty of Allied Health Sciences, KUNIV Teaching Clinical Chemistry courses (undergraduate/postgraduate levels) Research area: Pharmacogenomics and Membrane Biophysics.