Germany
DS Lead
- CMO correspondence - stability studies, CoAs - bridging studies - product specifications, potency assay - shipping of clinical supplies - IMPD, PSF
Preclinical R&D, CMC - virus production, neutralization assay - antibody production - epitope mapping, alanine scan, SDM, fusion assay - preclinical experiments (mouse model)
Establishing pipeline production of protein/ antibody secreting cell lines (CHO K1). Responsibilities: cloning, bacterial transformation, transfections, cell culture, FACS analysis, DNA & RNA isolation, genotyping (PCR), quantitative PCR, ELISA, documentation of progress & results
Team: applied R&D Projects: introduction of point mutations, generation of stress response pathway reporter cell lines & KO cell line production - using cutting edge CRISPR/Cas9 technology in stem cells and other diploid and haploid cell lines. Responsibilities: experimental design (gRNA, homology donors, primers), cloning, bacterial transformation, transfections, cell culture (iPSC), FACS analysis, DNA & RNA isolation, genotyping (PCR), TIDE analysis, TOPO-cloning, qPCR, reporter assays, lab maintenance and presenting progress & results.