Basel, Basel, Switzerland
Leading research activities based on flow cytometry, fluorescence microscopy and mass spectrometry spanning from basic research to clinical studies following GCP guidelines to dissect human immune responses ex vivo including major field co-variables such as strain variation, co-infections (HIV, CMV, malaria, and helminths) and co-morbidities (diabetes mellitus), aiming to refine our understanding of host-pathogen interaction for the rational development of drugs, diagnostic tools and vaccines against tuberculosis in particular.
Developing human granulomas models to study immuno-modulatory properties of selected compounds. Seeking biomarkers to monitor stem cell differentiation by mass spectrometry. Monitoring cellular immune responses in vaccine trials against malaria.
Assessing a flow cytometry assay (TAM-TB) for the diagnosis of tuberculosis in children.
Assessed human NK cell and macrophage responses to genetically distant M. tuberculosis strains
Studied the immune properties of specific compounds for the ex-vivo expansion of human NK cell for immunotherapy of selected cancers
Studied polyketides' role in mycobacterial cell wall biogenesis and virulence