Beerse, Flemish Region, Belgium
An experienced technical executive and Chartered Engineer with a proven track record in technical excellence, innovation & transglobal leadership. I have a balanced acumen in R&D and manufacturing in synthetics drug substance & product in Pharma and Consumer Healthcare sectors, and an extensive international experience at various tactical & strategic roles. I have an agile mindset and highly effective in a VUCA environment. A firm believer of ‘winning together’, I develop & bring out the best of people in a diversified team to enable high performance.
Key Responsibilities: Led a cross-functional multi-skilled AsiaPac & Japan team comprising of experts from pharmacy, chemistry, engineering, statistics and project management to provide above-site technical leadership to the global manufacturing sites, strategic regional CMO/CRO, and other functions to ensure the supply of pharmaceutical products, meeting supply chain quality & technical KPI targets and regulator’s compliance requirements. - Champion an AsiaPac quality improvement program to minimize the cost of poor quality & drive continuous improvement in the manufacturability of the key products - Lead a science & tech excellence initiative with a global cross-functional team to develop an enterprise Technology roadmap, and help designing an end-end business model of Science and Tech management - Deployment of technical capability uplift program for regional AZ sites and external CMOs - Actively support global & regional market growth activities: divestment/acquisition, new site establishment, development of new CMOs - Lead the portfolio resource management process for the Global Technical Service team
Key Responsibilities: Head of Technical organisation in a 24/7, fast-paced OTC & FMCG manufacturing facility. Managed two on-site technical teams to support day-to-day manufacturing of commercial supply, technical transfer of new products (NPI) from R&D and from/to third parties. In addition, led the technical assurance of Chinese CMO for outsourced products, provided technical oversight to external suppliers for performance improvement & assurance of licensed-in products, API, excipients, packaging material. - Piloted an integrated approach of product lifecycle management to provide process and product performance base-lining and reducing defects occurrence - Led site process improvement initiatives to enhance productivity and process robustness by reducing (repeated) deviations and defects - Led innovation projects to modernize manufacturing technology - Technical lead for Value Engineering projects to improve profit margin whilst enhancing product quality and functional benefits for customers, including products & services localization & source change - Support China business development activity via technical due diligence leadership
Key responsibilities: Established the NPI capability in a 24/7 manufacturing facilitity in China, and led a technical NPI team to provide technical excellence to support supply chain operation and value engineering activities. - NPI team leader in FMCG & OTC product area, and interfaces with R&D and Commercial to manage technology transfer of new products for the Chinese market - Manage source change projects for established products to achieve annual cost saving target - Site Champion for Technical Risk Assessment to improve process understanding & control for new and established products - Site Leader of a multi-disciplinary team to optimize manufacturing process performance
Key Responsibilities: Provided & led process engineering development to enable successful scale-up and technical transfer of R&D projects from lab to pilot plant and global manufacturing supply facilities. Also supported troubleshooting process robustness issues of post-approval API manufacturing processes across EMEA and AsiaPac sites - Process engineering team leader - managed resource allocation of new drugs development support, mentor and coach team members & placement students - Chemistry & Engineering team leader for Primary Tech Transfer from UK to Singapore manufacturing site, deploying QbD, Continued Verification and Targeted Development approach. The matrix team consists of 18 multi-disciplinary scientists and engineers. - Proven track record in the optimization of manufacturability and sustainability such as combining PAT & Engineering expertise to enhance process manufacturability and safety, troubleshooting & de-bottlenecking - Demonstrated ability to incubate, develop and implement innovative manufacturing technology solutions for process intensification and sustainability solution
The Influence of Ultrasonic Radiation on Solution-mediated Polymorphic Transformation - Led a project to elucidate the effect of ultrasound radiation on solution-mediated polymorphic transformation during crystallization using Synchrotron X-Ray at Daresbury facility (SAXS & WAXS) - Co-supervised PhD students, and managed research project procurement & budget
- Established impact of interfacial instabilities on pharmaceutical product quality using in-situ Atomic Force Microscopy (AFM) real time monitoring on organic crystal growth - Engineered a technology solution using oscillatory flow mixing (OFM) during crystallization to reduce manifestation of interfacial stability, thereby improving the quality of the API particles