New Orleans, Louisiana, United States
Lineage of disease, pathogens causing disease and micro-environments causing disease in a non-pathogenic situation. Connection between Eye and Brain Diseases, Small Cumulative Head Injuries into Full Blown TBIs and Complex Mental Disorders.
Teacher-Microbiology, Biology, Biochemistry, Human Anatomy, Physiology, Human Diseases and Immunology. Redefining disease as a lineage factor: Immunity and immune response are parts of the complex interactions of pathogenesis. However, physiological alertness and adaptability defines and shapes human response to exposure and this 'heightened state' could be heritable. Thus, in infectious inflammation and non-infectious inflammation, the former is triggered by the presence of a pathogen and the latter is triggered by micro-environments which induce similar response to an individual's excitable state and can result in full blown disease state without the presence of the pathogen. Micro-environments and pathogens are excitable inducers which can produce same or similar disease symptoms. Study of how viruses and bacteria-herpes simplex virus, adenovirus, MRSA etc invade human cells/tissue and cause pathogenesis. Drug delivery to posterior part of eye-use of nanoparticles in drug delivery; across blood-brain barrier-use of specialized antibodies and microcoil magnetic field technology. Testing of reformulated and new formulation of drugs on animal models for treatment of diseases- eye-herpetic stromal keratitis and neuronal-including Alzheimer's disease (AD). Development of anti-cancer isoflavones. Evaluation of Gene expression in disease conditions for identification of critical genes important in pathogenesis. Development of animal new models for diseases. We are closely studying inflammation, neovascularization, angiogenesis and molecules with signaling properties and their roles in infectious diseases and noninfectious conditions including traumatic brain injury (TBIs), dementia and AD. responses. R & D in testing small molecules and reformulations for ophthalmic, brain diseases, tumors and infectious diseases. Use of human cells/tissues to research the prevalence of herpesvirus (HSV) disease, EKC, retroviruses and facilitation of HIV by HSV.
APPLIED EXPERIENCE i.Novel therapies for treatment viruses-herpes simplex virus, adenovirus, HIV and bacteria-Pseudomonas, methicillin resistant Staph aureus. ii.Testing of reformulated and new formulation of drugs on animal models for treatment of diseases-eye and neuronal diseases-including Alzheimer's disease and traumatic brain injury (TBIs). iii.Development herbal/plant medicines including anti-cancer isoflavones. iv.Gene expression for identification of critical genes important in pathogenesis. vi.Drug development-phage display technology to yield non-toxic short peptides for treatment of viral, bacterial diseases and management of medical conditions. v.New therpies and drug development techniques in medicine and health research. vi. Animal models and tissue culture techniques for simulating disease and evaluating efficacy of drugs. CONSULTANCY i.Scoping ii.Environmental Management Plan for Industries and Real Estate iii.Environmental Monitoring for Workplace Air quality, Plant Liquid Effluent discharge quality for Oil refineries and plants for motor and industrial lubricating oils manufacture iv.Environmental Audit/Impact Assessment/Management Plans for Bulk Petroleum Storage and Transport v.Environmental Impact Assessment/Management Plans for manufacturer of intravenous infusions and allied products vi.Refurbishment of Analytical Laboratory and Operations for Certification and Accreditation for Goldmines and refineries. Isolation and Characterization of Local Sulfooxidizing Bacteria at the Obuasi Mine Site for Environmentally Friendly Gold Mining for Anglogold-Ashanti Co. vii.Survey of the Vegetation and Flora of Lagoon Salt Project Area and Natural preserve viii.Survey of the Vegetation and Flora of goldmine Concession Area. Restoration of flora and fauna at abandoned gold mining concession ix.Rehabilitation of Irrigation Projects and Water distribution.
My responsibilities included, basic research, pre-clinical research, testing of small molecules and reformulated drugs for efficacious therapy of diseases/disorders, development of new animal models for diseases including stromal keratitis, encephalitis and traumatic brain injury, training of postdocs, ophthalmology interns and lab staff and writing publications.