Milwaukee, Wisconsin, United States
Part of a team of PhD chemists working on process development of cGMP API's. - Subject matter expert in DoE. - Lead Scientist for continuous flow process development. - Lead on new equipment purchasing and installation. - EH&S liason for R&D.
Working under the direction of Dr. James M. Cook I. Synthesis and structure-activity-relationship (SAR) study of novel small molecule antibacterials active against MRSA and other life threatening gram-positive bacterial infections -Designed and synthesized novel small molecules (<300MW) with activity against all tested MRSA strains including VISA (vancomycin resistant S. aureus) -The most active compounds synthesized rival the activity of many antibacterials on the market, including so called "last resort" antibacterials II. Discovery of a new transition metal catalyzed route to novel dihydrobenzofurans. III. Synthesis and SAR study of pyrazoloquinolines ligands with subtype selective efficacy at GABA alpha 6 -Represent the first alpha 6 selective compounds discovered -May help elucidate the role alpha 6 receptors in cerebellar granule cells
Process improvement, verification, and scale-up from milligram scale to kilogram scale for flavor chemicals and API's.