Thousand Oaks, California, United States
- Medicinal chemist and project leader at Amgen, Inc. - >15 yrs Experience in academic and industrial organic synthesis - >15 yrs Experience as a mentor, supervisor, leader, and team-player - 36 Peer-reviewed publications, 55 patents/applications, 5 book chapters Specialties: - Medicinal chemistry - Solid- and solution-phase organic synthesis - Solid-phase peptide synthesis - GPCRs - Kinases - Protein-protein interactions - Covalent inhibitors - Inflammation - Oncology - Cardiovascular disease - Structure-based design - Research informatics - Combinatorial chemistry - Computational chemistry - Cross-functional management - External collaboration management - Hit-to-lead - Lead optimization
Project team lead for late-stage cardiovascular project (50+ person team). Chemistry lead (early & late optimization) for sotorasib (AMG 510) KRAS G12C covalent inhibitor program (15+ person chemistry team); delivered clinical development molecule on record timeline. Extensive modeling and research informatics experience (Maestro, MOE, Spotfire, Pipeline Pilot, Gaussian, in silico predictive models, etc.). Direct supervisor of six-person chemistry team.
Advisor: Larry Overman. Developed novel synthetic methods to access the bis-guanidine marine natural product palau’amine.