Stanford, California, United States
In the Gray lab, we are leveraging induced proximity to hijack proteins for event-driven pharmacology. Some of my recent work includes: • Pioneering the “Bump-Hole” PROTAC system to enable selective degradation of kinase gatekeeper mutants (ongoing). • Synthesizing the first selective bivalent degrader, designed to disrupt autophagic flux and enhance KRAS/MEK inhibitor efficacy in lung cancer (ongoing). • Developed transcriptional chemical inducers of proximity (TCIPs) that recruit transcriptional kinases to activate apoptotic gene expression in DLBCL.
In the Zhang Lab, we are interested in designing molecular sensors to monitor intermediate protein folding states. Some of my recent work includes: • Developed a general molecular strategy to enhance emissive properties in Donor-Acceptor Solvatochromic Chromophores. • Developed a high-fidelity fluorescence-based assay that detects disruptions in cellular proteostasis, advancing tools for studying protein quality control and stress responses.