Vienna, Vienna, Austria
•Currently leading a team of stem cell biologists, neuroscientists, neurophysiologists, and data scientists to develop the next generation CNS drug discovery platform. •Experience managing the R&D program of a biotech startup including external collaborations, presenting to investors, and interacting with large pharma companies at scientific and business levels. •Neuroscientist and stem cell biologist with research experience spanning multiple fields and diverse experimental platforms from neurodevelopment to neurological disease modeling. •Extensive expertise creating advanced 3D human brain organoid models. •Diverse training in multiple biological systems including human stem cells, fruit flies, and mice. •First-author publications in leading peer-reviewed journals and multiple prestigious fellowships awarded. •Passion for innovation that can change the boundaries of healthcare. •Dedicated to fostering a creative culture capable of finding new possibilities in life science. •Interest in outdoor activities involving mountains, with rock, snow, and ice.
https://aheadbio.com/
Investigated the role of genetic and epigenetic factors on the control of neuronal outgrowth and cell shape, specifically in regard to dendritic arborization. Also, through colloborative efforts with post-doctoral fellows in the lab, I explored the effect of poly-glutamine (polyQ) and TDP-43 proteins on dendritic arborization of neurons. These proteins are implicated in poly-glutamine repeat disorders, such as Huntington's Disease, and Amyotrophic lateral sclerosis (ALS) respectively.
Identified a role of brain derived neurotrophic factor (BDNF) in guiding migrating newborn neurons in the postnatal mouse brain as they travel from the subventricular zone to the olfactory bulb. Developed an acute slice assay allowing the monitoring of migrating neurons utilizing time-lapse confocal microscopy. The use of transgenic animals required learning and using skills to genotype and co-manage a mouse colony. Project culminated in the production of a research manuscript.
Determined the neuronal subtypes comprising a population of newborn neurons in the olfactory regions of postnatal mouse brain. Birth-dating newborn neurons in postnatal mouse brains to determine their expression profile of various markers of neuronal subtypes. Data analysis, figure creation, and writing of a research manuscript.