New York, New York, United States
I am a Senior Scientist with expertise in immuno-oncology and a passion for building research programs that connect patients, immunology, and therapeutic innovation. My work focuses on bladder cancer and head and neck cancer, where I leverage multiomic profiling and translational research approaches to uncover mechanisms of treatment response and resistance. In bladder cancer, I lead end-to-end translational research efforts spanning patient enrollment, biospecimen collection, biomarker discovery, and therapeutic development across the disease continuum. By integrating clinical observations with comprehensive immune response profiling, I aim to translate biological insights into actionable biomarkers and innovative therapeutic strategies. With training in pharmacy and immunology, and experience in both academia and industry, I bring a unique perspective that bridges clinical practice, translational research, and drug development. My research is driven by a simple principle: the most impactful discoveries emerge when clinical questions guide biological investigation and biological insights inform therapeutic innovation. My long-term goal is to build a translational oncology program that bridges academia, clinical programs, and industry, accelerating the development of actionable biomarkers and innovative immunotherapies for patients with cancer.
Project management; Cross-department collaborations; Oral presentations at department conferences; Gene editing (CRISPR KO)
PROJETS - Prédiction de l'efficacité de l'anticorps monoclonal Monalizumab et du BCG sur les fonctions anti-tumorales des cellules CD8T et NK chez les patients atteints de cancer de la vessie (co-supervision Dr. Nina Bhardwaj) - Rôle de HLA class I dans le développement des Innate Lymphoid cells (ILCs) et des cellules Natural Killer (NK) chez l'Homme TECHNIQUES Cytométrie de Masse (CyTOF), Cytométrie en flux Tests fonctionnels (Cytotoxicity assays) Culture cellulaire: Culture de lignées cellulaires et de cellules primaires, Expansion de lymphocytes CD8T Séquencage de cellule unique (scRNAseq) Olink, ELISA Extraction d'ADN COMPETENCES CLINIQUES Création de larges cohortes de patients Screening de dossiers médicaux Collaboration avec les départements cliniques INFORMATIQUE - Programmation sur R: Cluster analyses, t-SNE analyses, scRNAseq analyses, Trajectory analyses, Statistical tests - Graphpad Prism - Endnote, Zotero - Pack office CONNAISSANCES SCIENTIFIQUES - Biologie des cellules T, NK et ILC (Innate Lymphoid Cells) - Oncologie, Urologie - Education des cellules NK par le système HLA/KIR - Effets du Cytomégalovirus sur le système immunitaire ENSEIGNEMENT - Enseignante assistante à Summer Immunology Course of the Center for Excellence in Youth Education at Mount Sinai
PROJET PRINCIPAL: - Dysfonctionnement de cellules ILCs (Innate Lymphoid Cells) cytotoxiques dans la Leucémie Myéloide Aigüe https://ashpublications.org/bloodadvances/article/3/22/3674/428873/CD56-as-a-marker-of-an-ILC1-like-population-with PROJETS SECONDAIRES (co-auteur): - Étude du rôles des cellules ILCs dans: le cancer colo-rectal, le cancer de la vessie, la leucémie aigüe promyélocytaire et le mélanome https://www.jci.org/articles/view/89717 https://www.nature.com/articles/s41467-017-00678-2 https://www.frontiersin.org/articles/10.3389/fimmu.2019.02121/full https://cancerimmunolres.aacrjournals.org/content/8/4/556.long - Étude du transcriptome des cellules ILCs et des lymphocytes T CD4 https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.5MA0120-209R TECHNIQUES: Cytométrie en flux Séquencage d'ARN (RNAseq), Extraction d'ARN; PCR Luminex, ELISA Tests fonctionnels (Cytotoxicité...)
Characterization of Innate Lymphoid Cells in Human Cancer