Braine-le-Comte, Walloon Region, Belgium
Open to Scientist or Researcher Positions A passionate and dependable scientist with extensive expertise in medicinal and analytical chemistry, specializing in designing innovative small molecules and advancing the boundaries of scientific discovery. Holding a BSc and MSc in Thailand and a PhD in Bioscience Engineering from Ghent University, Belgium (earned through the prestigious Erasmus Mundus scholarship), I combine deep academic training with a robust professional track record. With a versatile skillset that spans mass spectrometry (MS, HRMS), chromatography (HPLC, UPLC, GC-MS), NMR, FTIR, and cell biology, I bring a comprehensive approach to solving complex scientific challenges. My hands-on experience includes method development/validation, peptide synthesis, and evaluating the stability and bioactivity of therapeutic compounds. I excel in both independent research and collaborative environments, contributing to projects ranging from polymer compendial testing to advanced therapeutic peptide optimization. Dedicated to excellence in R&D, I thrive in multidisciplinary and multicultural settings, bringing strong analytical skills, organizational reliability, and a drive for innovation. Let's connect to explore how my expertise can contribute to groundbreaking advancements in your organization.
At Baxter R&D Europe, I led chromatography-based method development and validation (HPLC, UPLC, GC-MS, LC-MS) for polymer analysis, driving innovation in material characterization across the product lifecycle. I ensured compliance with EP and USP standards through rigorous compendial testing and conducted annual quality assessments for PVC and non-PVC films, analyzing properties like TOC, UV, and FTIR. Additionally, I coordinated sterile cycle evaluations, external testing, and streamlined lab operations, maintaining safety and efficiency. My role combined technical expertise, protocol development, and a focus on advancing R&D efforts to enhance product performance and compliance.
Focus on peptide synthesis and peptide applications (eg stapled peptides and PROTACs) During my postdoctoral research at Ghent University, I focused on advancing therapeutic peptide design and optimization. I developed and refined synthesis strategies, including manual, microwave-assisted, and robotic methods, and explored innovative peptide stapling techniques using cholesterol derivatives to enhance drug profiles. My research included stability evaluations under enzymatic conditions and in human serum, as well as the biological characterization of purified peptides through assays like Western blotting and viability testing. I contributed to diverse projects, including scaling up peptide synthesis for bioconjugation (resulting in a patent application), synthesizing peptide-based PROTACs, and engineering hydrogels for controlled drug release. Additionally, I worked on cyclic peptide optimization for therapeutic applications and was instrumental in projects involving soluble peptide supports and analog synthesis for novel therapeutic strategies. Collaborating with multidisciplinary teams, supervising students, and embracing problem-solving challenges, I consistently pushed the boundaries of medicinal chemistry and bioprocess innovation.