Mölndal, Västra Götaland County, Sweden
Design and synthesis of single stranded oligonucleotides targeting protein binding motifs in condensate-relevant RNAs. Development of novel chemically modified PMO-nucleotides for the optimization of oligonucleotide potency and delivery. Synthesis of chemically modified oligonucleotides for secondary structure optimization.
Development of targeting and delivery strategies for oligonucleotide modalities into the lung. Development of siRNA- and ASO-conjugates, targeting specific lung cell lines. Lead finding and optimization of antisense oligonucleotides as therapeutic modalities in lung diseases.
Classical Medicinal Chemistry in a lead optimization program on small molecule kinase inhibitors.
Syntheses of novel nucleotide scaffolds and their use in oligonucleotide optimization. Development of an inhouse IP on hepatic siRNA-targeting. Project lead on the identification of novel small molecule ligands for siRNA-targeting. Chemical lead in therapeutic siRNA-projects. Responsible for scientific collaborations with partners from academia and biotech companies. Author and co-author of several patent applications and publications on novel nucleotide analogs and hepatic siRNA-targeting.
Classical Medicinal Chemistry in lead finding and optimization programs based on HTS-approaches, rational drug design and rescaffolding of literature compounds. Project lead and chemical lead in small molecule optimization programs on ion channels, kinases and proteases. Author and co-author of more than 35 patent applications and scientific publications on small molecule programs.
PhD in Natural Sciences PhD thesis in the research group of Prof. H. Kunz at the Institute of Organic Chemistry: "Carbohydrate substituted cyclopentadienes for the syntheses of chiral metallocenes". High experience in carbohydrate chemsitry and asymmetric catalysis.
Diploma in Chemistry Diploma thesis in the research group of Prof. H. Kunz at the Institute of Organic Chemistry: "Carbohydrate substituted cyclopentadienes and their complexation reactions"