Bonn, North Rhine-Westphalia, Germany
Experienced cell and molecular biologist focusing on functional genomics of human diseases. Past research work includes molecular studies on the role of cellular pathways such as inflammatory signaling cascades and autophagy in neurodegenerative diseases, cancer, metabolic disorders and infection. My main aim is to understand how both genomic variation and exogenous factors (environment, microbiom, life style,..) contribute to manifestation of human diseases and how this knowledge can be used for quicker, more precise diagnosis and, ultimately, personalized and tailored therapy.
The model project on Genome Sequencing under terms of § 64e SGB V, initiated by the Federal Ministry of Health (BMG) and starting in 2024, aims to establish genome medicine as fundamental pillar in the German health care system. The Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM) will govern establishment and operation of the core structure of this project, a decentralized data platform comprising pseudonymized clinical and genomic patient data.
Lab Head at the Med Clinic I (Section for Endocrinology, AG Fenske), focusing on the role of gut microbiota, immune signaling and neurobiology for manifestation of metabolic disorders
private lecturer and senior scientist focussing on the molecular framework that defines and shapes pathomechanisms of human diseases. Current research topics include: - autophagy dysregulation as decisive factor for proteinopathies - stem cell biology and its role for glioma therapy - innate immune responses to pathogens in the CNS Methodology: - classical cell line models and iPSC-derived disease models - high content imaging and quantitative image analysis - biochemistry, molecular biology and network-based computational approaches