Alyssa Jaffee

Partner, 7wire Ventures | Digital Health Investor | Board Director | Empowering Informed Connected Health Consumers

Chicago, Illinois, United States

About

I invest in companies that empower everyone to be better stewards of their health. As a Partner at 7wire Ventures, I focus on digital health and technology-enabled services that make care more personal, accessible, and effective. I currently hold board roles at NOCD, MedArrive, Brightline, Zerigo Health, Jasper Health, Summer Health, Transcarent, and the National Venture Capital Association (NVCA), where I collaborate with founders and industry leaders to shape the future of healthcare innovation. Beyond investing, I stay deeply engaged in the broader healthcare and business communities. I’m a member of the Business Leadership Council at WBEZ Chicago, the Oliver Wyman Leaders Alliance, and the Economic Club of Chicago, and I serve as a venture board member of Health Tech 4 Medicaid. I’m passionate about consumer-first innovation, value-based models, and building mission-driven companies that improve lives at scale. As a mom of 3, I am acutely aware of bettering our health and the health of the next generation.

Experience

  • Partner at 7wire Ventures
    Jan 2019 - Present · 7 yrs 6 mos

    Alyssa Jaffee is a Partner at 7wireVentures where she focuses on investments in digital healthcare and technology-enabled services that empower consumers to be better stewards of their health in today’s changing healthcare ecosystem. Alyssa serves on the boards of NOCD, MedArrive, Brightline, Zerigo Health, Jasper Health, Summer Health, and Transcarent.

  • Board Member at National Venture Capital Association
    2025 - Present · 1 yr 6 mos

  • Board Member at Summer Health
    Apr 2024 - Present · 2 yrs 3 mos

  • Board Member at NOCD
    Feb 2019 - Present · 7 yrs 5 mos

  • Board Observer at WellTheory
    Oct 2025 - Present · 9 mos