Frederick, Maryland, United States
Oncology Research
Pharmacodynamic Assay Development and Implementation Section (PADIS), Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Directorate, Leidos Biomedical Research Inc. (Formerly SAIC-Frederick), Frederick National Laboratory for Cancer Research. Assay development postdoctoral fellow with several years experience conducting independent research in support of biomarker development as part of a broader technical team supporting the drug development efforts of the National Cancer Institute. Development of slide-based multiplex immunofluorescence assays used to determine the global DNA repair protein profile in response to a variety of cytotoxic, genotoxic and targeted agents. Use of in vitro cell cultures and xenograft tumor models to establish assay fitness-for-purpose prior to use in clinical trial specimens. Development of assay for cross-platform utility, including slide-based microscopy and high-content imaging. Extensive validation and qualification of candidate biomarker panels. Development of analysis tools to quantify biomarker signals based on cellular localization pre and post-treatment.