Heidelberg, Baden-Württemberg, Germany
Synthetic organic chemist with a focus in medicinal chemistry, chemical biology and biochemistry with a well-developed theoretical knowledge and practical experience in diverse methods of organic chemistry synthesizing complex small molecules and natural products such as lipids and their multi-functionalized derivatives. Offering expertise in structured planning of (scientific) projects and their execution, well-structured presentations of results, comprehensive knowledge and interest in divers topics of research with well-developed communication and teamworking skills.
Synthetic chemical support (similar to a core facility) of research groups in a DFG funded SFB Transregio with custom synthesis of multi-functionalized lipids and other functionalized biological molcules for the exploration and elucidation of biological switches within cells. Project-dependent synthesis of deuterated lipids to use as standards for targeted lipidomic approaches
Organic synthesis and validation of a small molecule compound library, as a structure-activity relationship analysis tool for the development of an inhibitor. This also included the development of in-vitro assays to test the synthesized compound as well as cloning, expression and purification of the protein constructs needed in these assays.
Scientific collaboration partner of the Chemical Biology Core Facility to facilitate PhD reasearch project
Synthesis of Phosphatidylinositol-4,5-bisphosphate analogues as tool compounds for SAR of Phosphatase of Regenerating Liver 3 (PRL3)