Mechelen, Flemish Region, Belgium
As a Senior Principal Scientist at Johnson & Johnson Innovative Medicine, I am a dedicated, inquisitive leader with a broad technological interest, thriving in dynamic, high-tech R&D environments. My passion lies in fostering entrepreneurial and innovative settings where creativity and intellectual cross-pollination flourish, always with a strategic, holistic vision in mind. I excel at navigating complex, interdisciplinary challenges within expert and cross-functional CMC teams, driving product and process design from conception to commercialization. My work is focused on leveraging our rapidly evolving technological landscape to develop life-changing healthcare solutions, ensuring we capitalize on the momentum to realize its full potential. Beyond my technical achievements, I am committed to mentoring and guiding colleagues, enhancing team capabilities through leadership coaching and strategic collaborations with external partners. This role allows me to continuously evolve, interact with diverse teams, and balance analytical with creative thinking. I value personal connections, enjoying life through humor, music, gastronomy, and travel, which enrich my professional approach by fostering a collaborative, enjoyable work environment. Interests: Material Design Process and Product Development Advanced Drug Delivery Systems Technology Integration
In a 30h-course on design and development of pharmaceutical crystallization processes, Master students are exposed to the challenges and constraints of optimizing industrial unit operations. The practical aspects of the application of thermodynamics, kinetics, hydrodynamics and economics seamlessly complement their recently gained theoretical physical organic chemistry insights.
Cross-disciplinary Internal & External Collaboration: As project leader of multiple government funded external innovation projects bringing further integration on the drug substance - drug product (DS-DP) interface. Using holistic process and material understanding to aid identification of optimal process and product performance. Liason in many cross-industry consortia, competence groups and advisory boards. Scientific Leadership: Active involvement in long-term strategic excersizes on the further integration of drug substance - drug product (DS-DP) interface. Evaluation of the applicability of porous materials such as Metal Organic Frameworks (MOFs) for drug delivery. Scientific mentoring and supervision of early stage researchers including junior collegues, PhDs and post-doctoral scientists. Digital innovation: Automating time series analysis of continuous manufacturing runs for oral solid dosage forms combining various data sources.
Cross-disciplinary Internal & External Collaboration: As project leader of multiple government funded external innovation projects bringing further integration on the drug substance - drug product (DS-DP) interface. Examples include integrated long acting injectable suspensions development and continuous manufacturing, surface engineering of active ingredients using atomic layer deposition and non thermal plasma methods, holistic considerations for best process definition minimizing sustainability impact of oral solid dosage formulations. Liason in many cross-industry consortia, competence groups and advisory boards. Scientific Leadership: Active involvement in long-term strategic excersizes on particle tuning capabilities, future drug substance and drug product manufacturing methods and associated roadmap developments. Innovation project proposal writing and defending. Scientific mentoring and supervision of early stage researchers including junior collegues, PhDs and post-doctoral scientists. As a crystallization and solid-state characterization subject matter expert introducing experimental methods for intensification of experimental information density for data-driven decision making and de-risking. Digital innovation: Assure FAIR (Findable, Accessible, Interoperable, and Reusable) principles in all initiated data initiatives linking structural information, physical properties and process/product performance. Championing solid state informatics through definition, design and development of computational pipelines and workflows for early manufacturability assessment of new molecular entities (NMEs).
Scientific Leadership: Scientific leader and integrator in chemical process R&D overviewing the Janssen small molecule active ingredient portfolio across therapeutic areas. Respected member of cross-functional subject matter expert steering groups for portfolio review. Scientific Integration: Project management and logistical planning of active ingredient supply for pharmaceutical development. Involvemnet in due diligence on CMC aspects of small moleule assets. Digital innovation: Process understanding through advanced modeling e.g. thermodynamic solubility and phase diagram predication and regression, suspension image analysis for (near-)real time analysis and decision making. Data and modeling evangelist with a strong emphasis on scalability and democratization. Innovation champion for applied data sciences. New technology evaluation: Tailoring particle surface attributes for improved powder handling and biopharmaceutical performance through cross-disciplinary collaborations.
Fuga Moments selects, imports, markets, sells and distributes quality beverages to allow people to escape from daily-life stress and enjoying their lives by creating and sharing joyful moments with their loved ones, friends and family. The selection of the (sparkling) wines and beers is made under strict conditions regarding quality, affordability and taste. Mostly the chosen beverages are awarded our private fuga-label. In this way the products can be distinguished from the very wide (quality) range of wines and beers offered in Belgian supermarkets.
Structural chemist with a broad interest in new technologies and in particular in materials for Organic Electronics and Nonlinear Optics (NLO), specialized in the design of functional materials to obtain polar crystals. Besides experience gathered in organic synthesis of new oligomers of the PPV-type and their characterization and evaluation on a molecular level, crystal structure-activity relations were investigated by means of x-ray diffraction of single crystals of the bulk materials.
Synthese en karakterisatie van oligomere organische halfgeleiders van het PPV-type a.d.h.v. spectroscopische technieken en x-straaldiffractie (XRD) gecombineerd met het begeleiden en onderwijzen van studenten uit verschillende studierichtingen en opleidingsjaren.
Synthesis and characterisation of organic oligomeric semiconductors of the PPV-type using spectroscopic techniques and x-ray diffraction (XRD) combined with the education and supervision of students of different disciplines and years.